Producción Científica

Purpose: This study aimed to analyze articles on the diagnosis and treatment of bone and soft tissue sarcoma using positron emission tomography (PET)/computed tomography (CT) published in the last 13 years. The objective was to conduct a bibliometric analysis and identify the research hotspots and emerging trends. Methods: Web of Science was used to search for articles on PET/CT diagnosis and treatment of bone and soft tissue sarcoma published from January 2010 to June 2023. CiteSpace was utilized to import data for bibliometric analysis. Results: In total, 425 relevant publications were identified. Publications have maintained a relatively stable growth rate for the past 13 years. The USA has the highest number of published articles (139) and the highest centrality (0.35). The UDICE-French Research Universities group is the most influential institution. BYUN BH is a prominent contributor to this field. The Journal of Clinical Oncology has the highest impact factor in the field. Conclusion: The clinical application of PET/CT is currently a research hotspot. Upcoming areas of study concentrate on the merging of PET/CT with advanced machine learning and/or alternative imaging methods, novel imaging substances, and the fusion of diagnosis and therapy. The use of PET/CT has progressively become a crucial element in the identification and management of sarcomas. To confirm its efficacy, there is a need for extensive, multicenter, prospective studies.

Background: Migraine is a global public health concern, affecting both social and individual well-being. Calcitonin gene-related peptide (CGRP), a crucial neuropeptide, holds important research value in understanding migraine pathogenesis. CGRP receptor antagonists and monoclonal antibodies that target CGRP or its receptors have shown efficacy in reducing migraine frequency and severity, presenting a promising therapeutic approach. This study aimed to conduct a comprehensive bibliometric analysis to analyze the current state, research trends, and future directions of CGRP in migraine. Methods: Bibliometric tools including CiteSpace, VOSviewer, etc., were utilized to extract and summarize publications related to CGRP in migraine from the Web of Science Core Collection Database (WOSCC) between 2004 and 2023, as of December 31, 2023. The analysis focused on trends in annual publications, leading countries/regions and institutions, prominent journals and references, influential authors, and high-frequency keywords in the field. Results: A total of 1,821 articles and reviews involving 5,180 authors from 1,315 organizations across 64 countries were included in the study. These publications were distributed across 362 journals and accumulated 56,999 citations by December 31, 2023. An increasing trend was observed in annual publications on CGRP in migraine. The United States emerged as the leading nation in both publications and citations, with academic Peter Goadsby contributing the highest number of publications. The University of Copenhagen stood out as the institution with the most publications, and Cephalalgia emerged as the most influential journal. The most cited paper identified was “Calcitonin gene-related peptide receptor antagonist BIBN4096BS for the acute treatment of migraine” by Jes Olesen, published in the New Engl Med. Keyword frequency analysis revealed prevalent terms such as “migraine,” “CGRP,” and “episodic migraine,” along with emerging topics represented by keywords including “trial,” “monoclonal antibodies,” “preventive treatment,” and “safety.” Conclusion: CGRP is pivotal in migraine pathogenesis, and there is a robust research foundation exploring its role. The US leads in research output on CGRP in migraine. Investigating the mechanism of CGRP and its receptor in migraine remains a key area of interest, particularly focusing on signaling pathways. Future research should target identifying critical therapeutic targets in CGRP antagonist pathways for migraine treatment.

Objective Using bibliometric methods, this study analyzed and summarized the current situation and development of the global application of botulinum toxin in dermatology. Methods Literature published in the Web of Science Core Collection database from January 1, 2000 to October 28, 2023 was searched for topics such as “Botulinum toxin,” “Dermatology,” and so forth. The number of publications, countries, institutions, journals, authors, cited literature, keywords, and so forth, were analyzed and a visual knowledge map was created using scientometric tools such as CiteSpace, VOSviewer, and Scimago Graphica. Results A total of 2039 documents were retrieved and 1877 documents were included after de-duplication and transformation. The country with the highest number of published periodical articles was the United States; the main research institution was Yonsei University; the author with the highest number of published periodical articles was Kim, Hee Jin; and the high-frequency keywords mainly related to indications, combination therapy, and safety optimization. Conclusion The results of this study provide information on the current status and trends in clinical studies of botulinum toxin in dermatology, which will help researchers identify hotspots and explore new research directions in this field.

The outbreak of the COVID-19 has seriously affected the whole society, and vaccines were the most effective means to contain the epidemic. This paper aims to determine the top 100 articles cited most frequently in COVID-19 vaccines and to analyze the research status and hot spots in this field through bibliometrics, to provide a reference for future research. We conducted a comprehensive search of the Web of Science Core Collection database on November 29, 2023, and identified the top 100 articles by ranking them from highest to lowest citation frequency. In addition, we analyzed the year of publication, citation, author, country, institution, journal, and keywords with Microsoft Excel 2019 and VOSviewer 1.6.18. Research focused on vaccine immunogenicity and safety, vaccine hesitancy, and vaccination intention.

Background: Since human papillomavirus (HPV) infection is known as one of the main causes of cervical cancer, medical researchers pay significant attention to this issue2. The current study applies the bibliometric method to identify the trends and advancements of research on HPV worldwide. Methods: This descriptive study was conducted using a bibliometric approach. All HPV-related scientific publications in the Web of Science database until 2022, August 30 were included in the statistical population. The Bibliometrix package of the R programming language was used to analyze the data. Results: In the field of HPV, a total of 45,657 scientific publications were retrieved, the majority of which were articles. The countries with the highest publications were the USA (45,954 document), China (9977), and UK (6652). The words “Infection,” “Cancer,” and “Women” are the most important keywords of scientific publications on HPV. “Cancer,” “infection,” and “women” are the more developed and essential in HPV subject area. “Protein,” “gene-expression,” and “human-keratinocytes” are in this quadrant. “DNA,” “squamous-cell carcinoma,” and “head” keywords are basic themes in the HPV subject area. “Human-papillomavirus vaccination,” “knowledge,” and “attitude” are in this quadrant. Conclusion: The study suggests the need to enhance the focus on global and public health aspects within HPV research to encourage greater participation from various countries in international research endeavors.