Producción Científica

Background and objectives: Depression long been a key concern for scholars worldwide; however, the field of depression has not received sufficient attention in traditional Chinese medicine. It was not until the 21st century that research into depression gradually entered a period of rapid development, with an increasing number of academic studies published in major journals. However, one limitation of this field is that no scholars have yet summarised the development process and key research issues. Therefore, the present study aimed to summarise the research trends and progress in this field, providing relevant information and presenting potential future research directions for subsequent researchers. Methods: Literature in this field was searched from January 1, 2000 to April 20, 2024 in the Web of Science Core Collection database, to analyse the current status of the literature and publication trends. Bibliographic information, including study authors, organisations, keywords, countries, references, citations, and co-citations, was extracted using CiteSpace and VOSviewer software for quantitative analysis, visual mapping, and scientific evaluation. Results: A total of 921 papers were included, with a significant increase in the number of publications from 2017 to 2021, and a stable number of more than 140 publications between 2022 and 2023, with publications in these two years accounting for 31.38 % of the total. The Journal of Ethnopharmacology had the highest number of publications (97) and citations (2067), as well as the highest number of co-citations (1369). China (847 publications, 13256 citations), Beijing University of Chinese Medicine (90 publications, 1232 citations), and Qin Xuemei (30 publications, 759 citations) were the most prolific and influential countries, organisations, and authors in the field, respectively. Keyword clustering co-occurrence analysis revealed nine different clusters with good homogeneity. The top three clusters were randomised controlled trials, traditional Chinese medicine, and hippocampal neurogenesis. In the timeline analysis of keywords, from 2000 to 2010, keywords in this field were concentrated on hippocampal neurology and forced swimming test as clustering axes of Traditional Chinese Medicine. From 2010 to 2020, the research hotspots focused on randomised controlled trials and hippocampal neurogenesis. After 2020, keywords became more focused on network pharmacology. In addition, the occurrence time of explosive keywords were distributed before 2010 and after 2020. Before 2010, these keywords included the forced swimming test, Tail Suspension Test, Chronic Cold Stress, Neural Regeneration, and Banxia Houpu Decoction. Conversely, network Pparmacology and Molecular Docking arose as key buzzwords starting in 2020. Conclusions: This study comprehensively analysed and summarised the research hotspots and trends in this field of research in the 21st century from a bibliometric perspective, further generating a series of visual graphs to help researchers understand the current research status, potential collaborators, collaborating institutions, and potential future research hotspots in this field.

Background: The vascular endothelial growth factor (VEGF) signaling pathway is closely related to pathological angiogenesis in liver disease. Anti-angiogenesis is an effective intervention in the clinical treatment of liver disease. Some antiangiogenic drugs are resistant and have limitations in clinical use. Methods: This research uses bibliometric methods to assess the literature on the VEGF signaling pathway in liver disease from 2008 to 2023. Results: The number of publications has generally increased over the past 16 years, meaning that enormous researchers are interested in this field. China and the USA have published the most articles and cooperate closely with each other. Plos one has published the largest number of articles in this area, and Hepatology and Journal of Hepatology is the most authoritative journal. Llovet JM is an outstanding researcher in the field with the highest citations. Keywords and research hotspots analysis indicated that researchers are very concerned about the application and clinical research status of anti-angiogenic drugs in hepatocellular carcinoma (HCC). Continuing to deepen the research on the use of anti-angiogenic drugs alone and in combination is necessary. In addition, the resistance of anti-angiogenic therapeutic drugs leads to a complex mechanism of angiogenesis response caused by hypoxia, which requires further research. Conclusions: This study analyzed the research situation related to the VEGF signaling pathway in liver disease from a bibliometric and visual perspective. Our analysis helps researchers better understand the research directions and hotspots in this area, enabling them to better carry out research in the future.

Manufacturing bioactive materials for drug delivery involves developing materials that interact with biological tissues to release drugs in a controlled and targeted manner. The goal is to optimize therapeutic efficacy and reduce side effects by combining knowledge from materials engineering, biology, and pharmacology. This study presents a detailed bibliometric analysis, exploring the keywords “manufacturing,” “bioactive materials,” and “drug delivery” to identify and highlight significant advancements in the field. From the Web of Science, 36,504 articles were analyzed, with 171 selected for a deeper analysis, identifying key journals, countries, institutions, and authors. The results highlight the field’s interdisciplinary nature, with keywords grouped into four main themes, including regenerative medicine, scaffolds, three-dimensional (3D) printing, bioactive glass, and tissue engineering. Future research in this area will focus on more effective and precise systems using technologies like 3D printing and nanotechnology to enhance the customization and control of drug release, aiming for more efficient and targeted therapies.

Purpose: The rise of the coronavirus disease 2019 (COVID-19) pandemic has enabled researchers and industry professionals to reinvent their strategies for basic economic understanding. Two years after the outbreak of the pandemic, businesses are now trying to adapt to the impact it has brought, hoping to receive support as it did in the past. However, before this feat can be accomplished, it is imperative to understand the recovery hurdles created by the pandemic. This research aims to fill the literature gaps by examining the challenges during recovery within the creative small and medium-sized enterprise (SME) industry, as there are few relevant studies that focus on this field. Design/methodology/approach: Through a methodical bibliometric literature review and network analysis, the paper intends to critically explore relevant recovery challenges within the field while providing answers to the appropriate research questions. A total of 43 articles were selected for an in-depth review. Using the analysis from the selected articles as a guide, a framework was developed to address the recovery challenges alongside the recommended propositions. Findings: The findings from this paper suggest that a lack of synergy among four major categories (governmental, supply chain, organizational and stakeholders) contributes to recovery challenges within the field of research. Originality/value: The review also offers clarification in understanding the current and upcoming trends within the creative industry, SMEs and COVID-19. This paper can thus help researchers, industry practitioners and managers discover and analyze the recovery challenges brought about by the COVID-19 pandemic.