Producción Científica

Background: Although the number of studies on sorafenib for hepatocellular carcinoma (HCC) is increasing during the past two decades, no detailed scientometric examination of its knowledge framework has been undertaken. Therefore, we performed a bibliometric analysis on this topic. Methods: VOSviewer and CiteSpace were utilized to analyze the articles regarding sorafenib for HCC from 2005 to 2024, which were retrieved from the Web of Science Core Collection (WoSCC) database. Results: There were 7,667 articles related to sorafenib in HCC were retrieved from the WoSCC database, and they covered 99 countries/regions, 5,640 institutions, and 30,450 authors. The most published literature of countries and institutions were China and Sun Yat-sen University, respectively. Cancers is the journal with the most papers published in this field, and the journal with the most co-citations is N Engl J Med. Among authors, Masatoshi Kudo has published the most research papers, and the most co-citations go to JM Llovet. The keywords “survival”, “apoptosis”, “efficacy”, “transarterial chemoembolization”, “lenvatinib”, etc. represent the current hotspots in this field. Conclusions: We identified current hotspots and trends by bibliometric analysis in sorafenib-HCC field, which might provide valuable guidance for future researches. Further explorations are supposed to conduct the continued study of HCC apoptosis, large-scaled clinical trials with international cooperations, and comprehensive treatments including multiple systemic or locoregional approaches in patients with HCC.

In response to the growing demand for healthcare and the increasing importance people place on medical services, efficiently meeting these needs within the constraints of limited healthcare resources is of great social and economic benefit. Therefore, research into applying Large Language Models (LLMs) in the healthcare sector holds significant importance. This paper provides a review of the research progress on the application of LLMs in the healthcare field. First, the basic framework of LLMs is summarized, and the training process of LLMs in healthcare is systematically reviewed. Next, six specific application areas of LLMs in healthcare are reviewed: disease diagnosis and decision support, dissemination of medical knowledge, medical assistance, medical image analysis, biomedicine, and medical education. Then, several representative healthcare-specific LLMs are discussed, along with their performance analysis. Following this, the challenges faced by LLMs in healthcare are summarized, and relevant suggestions are provided. The future development trends of LLMs in healthcare are also explored. Finally, a bibliometric analysis is performed. Through the literature review, we found: 1) After pretraining, LLMs are widely adaptable to downstream tasks, significantly enhancing processing performance and efficiency; 2) LLMs in healthcare possess multiple capabilities and can handle multimodal data; 3) Bibliometric analysis shows that researchers are paying increasing attention to the application of LLMs in healthcare; 4) Further research is needed in optimizing, improving reliability, and expanding practical applications of large healthcare models.

Aim: Over the years, publications investigating the potential of various nutritional supplements, such as antioxidants, probiotics, and phytochemicals, to improve drug-induced nephrotoxicity have increased both qualitatively and quantitatively. This bibliometric analysis evaluated 100 highly cited articles on the protective effects of nutritional supplements against nephrotoxicity published between 2010 and 2023. Method: Articles published in these 13 years were evaluated through a structured search in Scopus and Web of Science databases. Statistics and visualization techniques were done using VOSviewer and RStudio software. Results: The increase rate of articles published on this subject was found to be %450. The average h-index of selected studies was calculated as 60. A total of 534 authors and a citation rate of 86.95 were determined. The total citation mean was defined as 9 per year. The top 3 supplements were curcumin (n=7), melatonin, and probiotics (n=5) in the trends. Cisplatin and gentamicin are used as toxic agents in 34% of the top 100 articles we researched, and they continue to be a trend. Conclusion: Curcumin, melatonin, berberine, quercetin, and probiotics are trending and effective supplements in this field. Based on our investigations, we think that the synergy between the effective bioactive ingredients and probiotics and/or other functional foods suggests future novel approaches based on interactions involving microbiota, oxidative, and inflammatory stress.

Context: Recent research has revealed significant advancements in the field of traditional Chinese medicine (TCM) for skin diseases. However, there is a lack of visualization analysis within this research domain. Objective: To analyze the research directions and advancements in TCM research in skin diseases. Materials and methods: Publications related to TCM in skin diseases from 2014 to 2024 were searched on the Web of Science Core Collection (WoSCC), VOSviewer, CiteSpace, and the R package “bibliometrix” were employed to visualize and analyze the retrieved data. Results: The study included 527 articles published in 25 countries. The number of publications consistently increased from 2014 to 2024. The Guangzhou University of Chinese Medicine was the most noteworthy institution in this field. Among the journals in this domain, the Journal of Ethnopharmacology was the most popular, and most frequently co-cited journal. Chuanjian Lu published the most papers and Yin-Ku Lin was the most frequently co-cited author. Among keywords, “psoriasis” appeared the most frequently. Additionally, several emerging research hotspots were identified, indicating the transition from traditional Chinese therapies to investigations of the molecular interactions and network pharmacology of Chinese herbs in treatment of skin diseases over the past decade. Discussion and conclusion: This visualization analysis summarizes the research directions and advancements in TCM research on skin diseases. It presents a comprehensive examination of the latest research frontiers and trends and serves as a valuable reference for scholars engaged in the study of TCM research.