Producción Científica

Background: Lung cancer possesses the highest incidence and mortality rates among malignancies globally. Despite substantial advancements in oncology, it is frequently diagnosed at an advanced stage, resulting in a poor prognosis. Over recent decades, the swift progress of nanotechnology has precipitated the extensive utilization of nanomaterials as carriers in cancer diagnosis and therapy. The deployment of nanoparticles as an innovative diagnostic strategy aspires to enable the earlier detection of lung cancer, thereby permitting earlier intervention and enhancing prognosis. This study endeavors to deepen our understanding of this domain through a comprehensive analysis employing bibliometric tools. Method: Related articles were retrieved from the Web of Science Core Collection from January 1st, 2006, to December 14st, 2023. Thereaf CiteSpace, VOSviewer and the online platform of bibliometrics (http://bibliometric.com/) were utilized to visually analyze Author/Country/Institutions/Cited Journals/Keyword, et al. Results: A total of 966 articles were retrieved for this study. The analysis unveils a progressive increase in annual publications within this field, with China at the forefront in publication volume, followed by the United States and India. Moreover, Chinese research institutions, notably the Chinese Academy of Sciences and Shanghai Jiao Tong University, prevail in publication output. Upon exclusion of irrelevant search terms, keywords clustering analysis highlights that “biomarkers”, “sensors”, “gold nanoparticles”, and “silver nanoparticles” are predominant research focuses. Conclusion: This bibliometric study furnishes a quantitative perspective on the extant literature, serving scholars in related fields. Furthermore, it anticipates future research trend concerning nanoparticles and lung cancer diagnosis, thereby aiding in the formulation of project planning and the design of experiments.

Background: Testosterone replacement therapy (TRT) is pivotal in addressing male hypogonadism, yet uncertainties persist regarding its optimal use and long-term ramifications. This study aims to explore the knowledge map of TRT. Methods: In this bibliometric study, we searched Scopus for relevant keywords from the beginning to 2023. Our inclusion criteria were original articles and reviews and our exclusion criteria were non-English and non-related articles and document types other than original articles and reviews. Excel, VOS viewer, and Science of Science (Sci2) software were used for data synthesis. Results: From 6712 retrieved articles, 5325 articles were included for analysis. The most productivity belonged to the USA (n=2, 570 documents), the United Kingdom (n=476), and Italy (n=339). “Journal of Clinical Endocrinology and Metabolism” (n=168) had the highest participation in publishing. Also, “Journal of Clinical Endocrinology and Metabolism” and the “Journal of Sexual Medicine” exhibited significant bibliographic coupling with other journals in the TRT field. The research topics of interest were mainly related to hypogonadism, prostate cancer, and erectile dysfunction. Bursting analysis of the title and abstract revealed the TRT research prior to the year 2000 was mainly focused on castration, gonadectomy, growth, and aplastic anemia, while the focus of recent research moved towards libido, cardiovascular events, HIV, geriatric issues, diabetes, bipolar disorder, cancer, transmasculine, and transgender individuals. Conclusion: This study highlights the growing trend of TRT research over time, with most focus on hypogonadism, prostate cancer, and erectile dysfunction. Insights gleaned from this analysis inform research priorities and resource allocation, facilitating enhanced patient care in androgen deficiency management.

Background: Postoperative infections in artificial joints provide considerable difficulties in the field of orthopedics, especially after joint replacement procedures. These infections rank among the most severe postoperative consequences, frequently leading to treatment ineffectiveness and reduced quality of life for surgery patients. Consequently, it is crucial to acquire knowledge about worldwide research trends in this area in order to educate clinical practices and improve therapeutic techniques. This work exploits bibliometric analysis to investigate the present state, developing patterns, and main areas of focus in research on artificial joint infection. Objective: To analyze the research trends, hotspots, and international collaborations on artificial joint infections worldwide from 2013 to 2023. Methods: Extractions of raw data were made from the WoSCC (Web of Science Core Collection) database. Detailed information collected includes the quantity of publications, authors, citations, publication year, h-index, references, country/region, journal, and keywords. Analysis of the data was conducted using VOSviewer version 1.6.10.0 and CiteSpace version 6.3.R1. Results: A total of 1,799 articles published between 2013 and 2023 were included in this analysis, showing a steady increase in publication with the United States leading at 553 articles. Infection rates and topics such as biofilm formation and antimicrobial resistance were highly cited, with Mayo Clinic contributing 65 articles as the most prolific institution. Conclusion: Research on biofilm infections, antibiotic resistance, and new biomarkers is a key focus, particularly on disrupting biofilms and enhancing diagnostics. There’s growing attention in biomarkers like α-defensins and exosomal miRNAs for PJI diagnosis, pointing to new clinical uses. Studies on antimicrobial-coated prosthetics and topical agents are also gaining importance in treatment strategies.