Producción Científica

Background: Autophagy is a cellular process in which damaged organelles or unnecessary proteins are encapsulated into double-membrane structures and transported to lysosomes for degradation. Autophagy plays a crucial role in various liver diseases, including nonalcoholic fatty liver disease. This study aims to elucidate the role of autophagy in nonalcoholic fatty liver disease through bibliometric analysis. Methods: Literature was retrieved from Web of Science CoreCollection database, and the search time was from January 01, 2004 to December 31, 2023. Data retrieval was performed using the Bibliometrix package in R software. VOSviewer and CiteSpace were utilized to visualize the research hotspots and trends related to the effect of autophagy on nonalcoholic fatty liver disease. Results: A total of 966 papers were obtained, published in 343 journals from 1385 institutions across 57 countries. The journals with the most publications were the “International Journal of Molecular Sciences”and “Scientific Reports.”China had the highest number of published papers. The most productive authors were Yen Paul M and Jung Tae Woo, while Singh R was the most frequently co-cited author. Emerging research hotspots were associated with keywords such as insulin resistance, ferroptosis, endoplasmic reticulum stress, and mitochondrial function. Conclusion: Research on autophagy in nonalcoholic fatty liver disease is still in its early stages, with a growing body of literature. This study is the first to provide a comprehensive bibliometric analysis, synthesizing research trends and advancements. It identifies current development trends, global cooperation models, foundational knowledge, research hotspots, and emerging frontiers in the field.

Background: Sonodynamic therapy (SDT) is a non-invasive cancer treatment technique stemming from photodynamic therapy (PDT) and has garnered escalated interest among researchers in recent years. Numerous aspects of cancer SDT remain contentious, and the global research trajectory within this domain remains insufficiently explored. This study seeks to delineate the comprehensive knowledge framework, developmental trends, and pivotal research focal points concerning cancer SDT. Methods: The study retrieved documents on cancer SDT from the Web of Science Core Collection (WoSCC) database spanning from 1 January 2000 to 7 December 2023. Bibliometric visualization was carried out through the utilization of CiteSpace 6.2 R6, VOSviewer 1.6.20, and an online analytical platform. Several bibliometric techniques including co-authorship, co-citation, co-occurrence, cluster, as well as burst analysis were used. Results: A total of 672 publications including 603 articles and 69 reviews were included. The annual publication count exhibited a steady increase over time, notably experiencing a surge, particularly in recent years. In terms of contributors, China has maintained its prominent position with the highest outputs and the most financial support. Chinese Academy of Sciences contributed the most articles. Materials Science was the most investigated research areas. Breast cancer emerged as the most extensively studied tumor, succeeded by sarcoma, hepatocellular carcinoma, melanoma, pancreatic cancer, glioma. According to co-cited references, “harnessing nanomaterial”, “sonodynamic precision tumor therapy” and “metal-organic framework” denote the current and emerging research focuses within the field. In tandem with the results from keywords co-occurrence and burst, we identified the following research topics including mechanism of induced cell death (ferroptosis, immunogenic cell death), nano-related research (nanoplatform, nanozymes, nanomaterials, nanosheets, metal-organic frameworks (MOFs), nanocomposites, nanoparticles, nanosonosensitizers, liposomes, nanocarriers), combination therapies (chemodynamic therapy, immunotherapy, radiotherapy, photothermal therapy), and tumor microenvironment (hypoxia, singlet oxygen, oxidative stress), that may remain the research hotspots and receive sustained attention in the near future. Conclusions: For the first time, this bibliometric analysis not only presents a comprehensive portrayal of the knowledge framework, but also delineates shifts in research focal points related to cancer SDT within the last two decades. This systematic summarization offers a comprehensive and lucid comprehension of cancer SDT, providing valuable insights for further investigations in this domain.

The increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE) poses a significant threat to public health. CRE, particularly Klebsiella pneumoniae, is associated with high morbidity and mortality owing to limited treatment options. This study identifies current research trends, major topics, and future directions in the scientific field of CRE. We systematically retrieved publications from the Web of Science database starting from 2020 to January 07, 2024. Using bibliometric tools such as VOSviewer, CiteSpace, and InCites, we analyzed publication counts, citation analysis, co-authorship, keyword co-occurrence, and thematic development to map the landscape and collaborative networks in the field. The search included keywords such as “carbapenem-resistant Enterobacteriaceae,””carbapenemase-producing Enterobacteriaceae,””carbapenemase-producing Klebsiella pneumoniae,”and “Klebsiella pneumoniae carbapenemase.”We reviewed 1946 articles. The largest contributors to the field were China, the United States, and Italy. This study highlights the significant increase in CRE-related publications, particularly in the context of hospital-acquired infections, antimicrobial resistance mechanisms, and novel therapeutic approaches. Keyword trend analysis revealed epidemiology, molecular biology, infection control, and public health implications, signaling a shift towards the broader impact of CRE in healthcare settings. This bibliometric analysis maps the current research landscape and identifies key areas for further research. Continued progress is essential to develop strategies to combat antimicrobial resistance and to improve patient outcomes.