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PT AU BA BE GP AF BF CA TI SO SE BS LA DT CT CY CL SP HO DE ID AB C1 C3 RP EM RI OI FU FP FX CR NR TC Z9 U1 U2 PU PI PA SN EI BN J9 JI PD PY VL IS PN SU SI MA BP EP AR DI DL D2 EA PG WC WE SC GA PM OA HC HP DA UT J Martins, ML; Leite, KLD; Magno, MB; Masterson, D; Vicente-Gomila, JM; Cavalcanti, YW; Maia, LC; Fonseca-Goncalves, A Martins, Mariana Leonel; de Franca Leite, Karla Lorene; Magno, Marcela Barauna; Masterson, Daniele; Miguel Vicente-Gomila, Jose; Cavalcanti, Yuri Wanderley; Maia, Lucianne Cople; Fonseca-Goncalves, Andrea The Xylitol Applicability and its Effects in Health Area Worldwide: A Bibliometric Analysis Based on Randomized Controlled Trials PESQUISA BRASILEIRA EM ODONTOPEDIATRIA E CLINICA INTEGRADA English Article Xylitol; Therapeutics; Randomized Controlled Trials as Topic; Bibliometrics SALIVARY MUTANS STREPTOCOCCI; SUBSP LACTIS BB-12; CHEWING-GUM; CLINICAL-TRIAL; DENTAL-CARIES; DOUBLE-BLIND; GUSTATORY STIMULANTS; BOWEL MOTILITY; OTITIS-MEDIA; DRY MOUTH Objective: To describe and evaluate the xylitol products' applicability and its effects in the health area worldwide utilizing a bibliometric analysis from randomized controlled trials (RCT) with humans. Material and Methods: Electronic searches were carried out in Medline/PubMed, Scopus, Cochrane Library, Web of Science, and VHL databases. The main data extracted were: year, area of applicability, type of treatment, country, journal, xylitol posology and concentration, presentation form, outcomes, and effects. Results: From 1476 studies, 257 were included. These studies were published between 1973-2021. The majority was carried out in dentistry (78.9%) and under preventive treatment (67.4%). These studies were developed in the USA (15.4%) and published in Caries Research (6.6%). The posology and concentration ranged between 0.004-67 g/day and 0.002-100%, respectively. The xylitol is usually used in the chewing gum form (44.0%), and for antimicrobial activity evaluation (38.5%). A positive effect was observed in 204 studies (79.3%) and was associated with xylitol concentration >= 15% (p=0.007). Side effects were reported in 8.2% and were associated with posology >= 5 g/day (p=0.05). Conclusion: Most studies with xylitol were conducted to prevent diseases in the dentistry field. The chewing gum form and antimicrobial activity evaluation were more frequent. Most xylitol products have a positive effect, and few studies report side effects. [Martins, Mariana Leonel; de Franca Leite, Karla Lorene; Magno, Marcela Barauna; Maia, Lucianne Cople; Fonseca-Goncalves, Andrea] Univ Fed Rio de Janeiro, Sch Dent, Dept Pediat Dent & Orthodont, Rio De Janeiro, RJ, Brazil; [Masterson, Daniele] Univ Fed Rio de Janeiro, Hlth Sci Ctr, Cent Lib, Rio De Janeiro, RJ, Brazil; [Miguel Vicente-Gomila, Jose] Univ Politecn Valencia, Dept Engn Projects, Madrid, Spain; [Cavalcanti, Yuri Wanderley] Univ Fed Paraiba, Dept Clin & Social Dent, Joao Pessoa, Paraiba, Brazil Universidade Federal do Rio de Janeiro; Universidade Federal do Rio de Janeiro; Universitat Politecnica de Valencia; Universidade Federal da Paraiba Fonseca-Goncalves, A (corresponding author), Rua Prof Rodolpho Paulo Rocco 325,Cidade Univ, BR-21941971 Rio De Janeiro, RJ, Brazil. andrea.goncalves@odonto.ufrj.br leite, karla/GPX-3607-2022; Cavalcanti, Yuri/C-3152-2012; Fonseca-Goncalves, Andrea/I-4223-2012 Ferreira, Daniele/0000-0001-7108-1117; Maia, Lucianne/0000-0003-1026-9401; Cavalcanti, Yuri/0000-0002-3570-9904; Martins, Mariana Leonel/0000-0001-6777-3225; Leite, Karla/0000-0002-0113-6810; Fonseca-Goncalves, Andrea/0000-0001-6467-7078 Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brazil (CAPES) [001]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [401058/2016-6] Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brazil (CAPES)(Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)(Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)) This study was financed in part by the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brazil (CAPES) -Finance Code 001, and had financial funding from the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) -Process No. 401058/2016-6 -for the VantagePointT software. 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Bras. Odontopediatria Clin. Integr. 2022 22 e210046 10.1590/pboci.2022.011 http://dx.doi.org/10.1590/pboci.2022.011 18 Dentistry, Oral Surgery & Medicine Emerging Sources Citation Index (ESCI) Dentistry, Oral Surgery & Medicine YT6KR gold 2023-01-16 WOS:000751466800001