Artículo

Global biomarker trends in triple-negative breast cancer research: a bibliometric analysis

Resumen

BACKGROUND: Triple-negative breast cancer (TNBC) is defined as breast cancer that is negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) in cancer tissue. The lack of specific biomarkers makes the diagnosis and prognosis of TNBC challenging. METHOD: A comprehensive literature review and bibliometric analysis was performed using CiteSpace, VOSviewer and Scimago Graphica. RESULTS: TNBC biomarker research has been growing rapidly in recent years, reflecting the enormous academic interest in TNBC biomarker research. A total of 127 journals published relevant studies and 1749 authors were involved in the field, with developed countries such as the United States, France, and the United Kingdom contributing greatly to the field. Collaborative network analysis found that the research in this field has not yet formed good communication and interaction, and the partnership should be strengthened in the future in order to promote the in-depth development of TNBC biomarker research. A comprehensive analysis of keywords and co-cited literature, etc. found that TNBC biomarker research mainly focuses on immune checkpoint markers, microenvironment-related markers, circulating tumor DNA, metabolic markers, genomics markers and so on. These research hotspots will help to better understand the molecular characteristics and biological processes of TNBC, and provide more accurate biomarkers for its diagnosis, treatment and prognosis. CONCLUSIONS: The bibliometric analysis highlighted global trends and key directions in TNBC biomarker research. Future developments in TNBC biomarker research are likely to be in the direction of multi-omics integration, meticulous study of the microenvironment, targeted therapeutic biomarkers, application of liquid biopsy, application of machine learning and artificial intelligence, and individualized therapeutic strategies. Young scholars should learn and collaborate across disciplines, pay attention to new technologies and methods, improve their data analysis skills, and continue to follow up on the latest research trends in order to meet the challenges and opportunities in the field of TNBC biomarkers.
Bulto, Tadesse Weyuma (57218921685); Chebo, Abdella Kosa (57211658384); Regassa, Hailu Fufa (59527811700); Werku, Birhanu Chalchisa (57793656500); Kloos, Helmut (26643043000)
Scientific mapping of the nexus between entrepreneurial orientation and environmental sustainability: bibliometric analysis
2024
10.3389/fsoc.2024.1461840
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85216004215&doi=10.3389%2ffsoc.2024.1461840&partnerID=40&md5=eb475c40557b00c5f84aa42ba2e3e68d
Department of Management, Kotebe University of Education, Addis Ababa, Ethiopia; Department of Business Management, University of Johannesburg, Johannesburg, South Africa; Department of Sociology, Ambo University, Oromia, Ethiopia; Faculty of Resource Management and Economics, Wollega University, Nekemte, Ethiopia; Department of Rural Development and Agricultural Extension, Jimma University, Jimma, Ethiopia; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, United States
All Open Access; Gold Open Access
Scopus
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