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Comprehensive retrospect and future perspective on bacteriophage and cancer

Resumen

Background: Researchers gradually focus on the relationship between phage and cancer. Objective: To summarize the research hotspots and trends in the field of bacteriophage and cancer. Methods: The downloaded articles were searched from the Web of Science Core Collection database from January 2008 to June 2023. Bibliometric analysis was carried out through CiteSpace, including the analysis of cooperative networks (country/region, institution, and author), co-citations of references, and key words.Visual analysis of three topics, including gut phage, phage and bacteria, and phage and tumor, was conducted. Results: Overall, the United States and China have the most phage-related research. In terms of gut phage, the future research directions are “gut microbiome”, “database” and “microbiota”. The bursting citations explored the phage-dominated viral genome to discover its diversity and individual specificity and investigated associations among bacteriome, metabolome, and virome. In terms of phage and bacteria, “lipopolysaccharide” and “microbiota” are future research directions. Future research hotspots should mainly concentrate on the further exploration and application of phage properties. As for phages and tumors, the future research directions should be “colorectal cancer”, “protein” and “phage therapy”. Future directions are likely to focus on the research on phages in cancer mechanisms, cancer diagnosis, and cancer treatment combined with genetic engineering techniques. Conclusion: Phage therapy would become a hot spot and research direction of tumor and phage research, and the relationship between phage and tumor, especially colorectal cancer (CRC), is expected to be further explored.
Carrasco, Ingrid Bravo (58283373900); Riquelme-Mella, Enrique (58415000900); Saldivia, Ximena Gutiérrez (58505202000); Fuentes-Vilugrón, Gerardo (57224782844)
Education of the Affective Ideal in Contexts of Cultural Diversity: BIBLIOMETRIC and Thematic Analysis (2006-2021)
2023
10.15379/ijmst.v10i2.1391
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85165695711&doi=10.15379%2fijmst.v10i2.1391&partnerID=40&md5=159bc31bf0db6c44b3a219b898c273c8
Universidad del Bio Bio, Chile, Universidad de Concepción, Chile; Facultad de Educación, Núcleo de Estudios Interétnicos e Interculturales (NEII), Universidad Católica de Temuco, Chile; Facultad de Ciencias Sociales, Carrera de Psicología, Universidad Santo Tomas, Chile; Universidad Católica de Temuco, Chile; Facultad de Educación, Carrera de Pedagogía en Educación Física, Universidad Autónoma de Chile, Chile
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