Comprehensive retrospect and future perspective on bacteriophage and cancer 2024

Background: Researchers gradually focus on the relationship between phage and cancer. Objective: To summarize the research hotspots and trends in the field of bacteriophage and cancer. Methods: The downloaded articles were searched from the Web of Science Core Collection database from January 2008 to June 2023. Bibliometric analysis was carried out through CiteSpace, including the analysis of cooperative networks (country/region, institution, and author), co-citations of references, and key words.Visual analysis of three topics, including gut phage, phage and bacteria, and phage and tumor, was conducted. Results: Overall, the United States and China have the most phage-related research. In terms of gut phage, the future research directions are “gut microbiome”, “database” and “microbiota”. The bursting citations explored the phage-dominated viral genome to discover its diversity and individual specificity and investigated associations among bacteriome, metabolome, and virome. In terms of phage and bacteria, “lipopolysaccharide” and “microbiota” are future research directions. Future research hotspots should mainly concentrate on the further exploration and application of phage properties. As for phages and tumors, the future research directions should be “colorectal cancer”, “protein” and “phage therapy”. Future directions are likely to focus on the research on phages in cancer mechanisms, cancer diagnosis, and cancer treatment combined with genetic engineering techniques. Conclusion: Phage therapy would become a hot spot and research direction of tumor and phage research, and the relationship between phage and tumor, especially colorectal cancer (CRC), is expected to be further explored.

Autores	Liping, Zhong (57202904585); Sheng, Yu (59403542900); Yinhang, Wu (57227402100); Yifei, Song (58061956400); Jiaqun, Huang (59403558600); Xiaojian, Yu (59225868900); Shuwen, Han (56089782700); Jing, Zhuang (57211318700)
Título	Comprehensive retrospect and future perspective on bacteriophage and cancer
Año	2024
DOI	10.1186/s12985-024-02553-1
Fuente	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85208603280&doi=10.1186%2fs12985-024-02553-1&partnerID=40&md5=418f9b3908887ddac431883007c7b64e
Afiliaciones	Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, No.1558, Sanhuan North Road, Wuxing District, Zhejiang Province, Huzhou, 313000, China; Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Zhejiang Province, Huzhou, 313000, China; Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer of Huzhou, Zhejiang Province, Huzhou, 313000, China; ASIR (Institute – Association of intelligent systems and robotics), 14B rue Henri Sainte Claire Deville, Rueil-Malmaison, 92500, France
Tipo de acceso abierto	All Open Access; Gold Open Access
Referencia	Scopus
Artículo obtenido de:	Scopus

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Comprehensive retrospect and future perspective on bacteriophage and cancer

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