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Bipolar disorder and oxidative stress: A bibliometric perspective

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Objective: Accumulating evidence indicates that oxidative stress and the disruptionof antioxidant defenses play an important role in the neurobiology of bipolar disorder(BD). Studies have found that increased oxidative stress may be associated with cellapoptosis and neuronal damage in BD patients. Hence, this study explored theresearch field related to BD and oxidative stress from a bibliometrics perspective. Methods: Literature search and relevant data retrieval based on the Web of SciencesCore Collection (WoSCC). R software (version 4.2.2), VOSviewer software (version1.6.18), and CiteSpace (version 6.1.6) were used in this bibliometric analysis. Results: A total of 2081 publications related to BD and oxidative stress were pub-lished between 1986 and 2024. Bipolar Disorders was the journal that had the mostpublications in this area (72; 3.46%; IF = 5.9), while the United States (1285; 61.7%)and the University of Toronto (377; 18.1%) were the most productive country andinstitution, respectively. Apart from “oxidative stress” and “bipolar disorder,” the most frequently used keywords were “schizophrenia,” “prefrontal cortex,” and “nitricoxide.” Conclusions: The growing number of publications related to BD and oxidative stressin recent years highlights the importance of this research field. Hot topics in researchrelated to BD and oxidative stress included animal experiments and molecular mecha-nisms, psychiatric-related inflammation and biomarkers, neurodegenerative diseases,and metabolism. Furthermore, the biological mechanisms of BD, particularly bio-markers and inflammation, may be the emerging research priority area in the future.
Jia, Hongying (59471412300)
A review of research progress in the design history of everyday life
2025
10.1016/j.heliyon.2024.e40865
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85211984792&doi=10.1016%2fj.heliyon.2024.e40865&partnerID=40&md5=5c58bbe4f9ad1afbb0b67fb0223849fd
Tongji University, College of Design and Innovation, Shanghai, China
All Open Access; Gold Open Access
Scopus
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