Artículo

Bibliometric Analysis of the Role of Occludin in the Pathogenesis of Stroke

Resumen

Over the past decade, there has been a notable surge in research dedicated to unraveling the intricate role of tight junction proteinsin blood–brain barrier (BBB) damage associated with ischemic stroke. This bibliometric analysis explores the expansive landscapeof occludin research, a key tight junction protein, during the years 2000–2023, shedding light on the global scientific contributions,collaborations, and emerging trends in this critical area of stroke pathogenesis. China and the United States emerge as significantcontributors, underscoring their prominence in advancing our understanding of tight junction proteins. Occludin, identified as alinchpin in regulating BBB integrity, proves to be a pivotal player, with implications extending to the diagnosis of hemorrhagictransformation in ischemic stroke. This study identifies occludin as a potential biomarker, offering promise for early diagnosis andpaving the way for novel diagnostic strategies. The analysis highlights the necessity for a more comprehensive exploration of tightjunction proteins, including occludin and claudin-5, particularly in the context of acute cerebral ischemia. The unique healthcarelandscape in Kazakhstan adds urgency to the call for further scientific research in this region, emphasizing the need for tailoredinvestigations to address specific regional challenges. This comprehensive overview not only delineates the current state of occludinresearch but also signals the direction for future investigations. The identified knowledge gaps and emerging trends provide aroadmap for researchers and policymakers alike, with implications for both scientific discourse and clinical practice. Movingforward, a deeper understanding of tight junction proteins, informed by the insights gleaned from this study, holds the potential toshape targeted therapeutic interventions and diagnostic strategies, ultimately contributing to advancements in global stroke care.
Autores
Vilela, JMD; Faria, JR
Título
Industry 4.0 and 5g technology on firms network: a balanced competitive expansion conceptual model development
Afiliaciones
Universidade Federal Fluminense
Año
2022
DOI
10.14488/BJOPM.2022.1426
Tipo de acceso abierto
gold
Referencia
WOS:000811447300003
Artículo obtenido de:
WOS
Fuente
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