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Artículo

Mapping the scientific output of organoids for animal and human modeling infectious diseases: a bibliometric assessment

Resumen

The escalation of antibiotic resistance, pandemics, and nosocomial infections underscores the importance of research in both animal and human infectious diseases. Recent advancements in three-dimensional tissue cultures, or “organoids”, have revolutionized the development of in vitro models for infectious diseases. Our study conducts a bibliometric analysis on the use of organoids in modeling infectious diseases, offering an in-depth overview of this field’s current landscape. We examined scientific contributions from 2009 onward that focused on organoids in host‒pathogen interactions using the Web of Science Core Collection and OpenAlex database. Our analysis included temporal trends, reference aging, author, and institutional productivity, collaborative networks, citation metrics, keyword cluster dynamics, and disruptiveness of organoid models. VOSviewer, CiteSpace, and Python facilitated this analytical assessment. The findings reveal significant growth and advancements in organoid-based infectious disease research. Analysis of keywords and impactful publications identified three distinct developmental phases in this area that were significantly influenced by outbreaks of Zika and SARS-CoV-2 viruses. The research also highlights the synergistic efforts between academia and publishers in tackling global pandemic challenges. Through mostly consolidating research efforts, organoids are proving to be a promising tool in infectious disease research for both human and animal infectious disease. Their integration into the field necessitates methodological refinements for better physiological emulation and the establishment of extensive organoid biobanks. These improvements are crucial for fully harnessing the potential of organoids in understanding infectious diseases and advancing the development of targeted treatments and vaccines.
Liu, Qian (58043907500); Yang, Shijie (59167076100); Chen, HeCheng (57203946435)
Global trends and hotspots in the study of the effects of PM2.5 on ischemic stroke
2024
10.1186/s41043-024-00622-3
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85202738639&doi=10.1186%2fs41043-024-00622-3&partnerID=40&md5=2f80b4bf91836970169230f4633fc742
Cerebrovascular Disease Department, Gansu Provincial Hospital, No.204 West Donggang Road, Gansu Province, Lanzhou, 730000, China; Key Laboratory of Cerebrovascular Disease of Gansu Province, Gansu Provincial Hospital, Gansu, Lanzhou, China; The First Clinical Medical College of Lanzhou University, Lanzhou, China
All Open Access; Gold Open Access
Scopus
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