Artículo

A review of Ribosome profiling and tools used in Ribo-seq data analysis

Resumen

Translational regulation plays the most critical role in gene expression. Ribosome profiling sequencing (Ribo-Seq) is one of the methods to study translation and its regulation. It is a high throughput technology based on deep sequencing, which targets ribosome protected mRNA fragments to produce a ‘global snapshot’ of translatome. There has been an annual increase in the number of publications incorporating Ribo-seq technology. Because of its importance, we used PubMed database to conduct a comprehensive bibliometric analysis on Ribo-seq. We identified 2744 published articles that utilized the term ‘Ribo-seq’ between 2009 and Jan 2024, and 684 articles that contained both Ribo-seq and RNA-seq terms. Based on keywords correlation analysis, we discovered that the primary focus of Ribo-seq articles lies in the areas of translation, transcriptome, and ribosome in the past few years and other topics such as single-cell ribo-seq and crispr within two years, reflecting current areas of interests in Ribo-seq research. The Ribo-seq data analysis applications were also explored and summarized, providing a guide for researchers to choose corresponding tools for different types of analysis. Overall, we highlighted the advances made by Ribo-seq technologies, and the possibilities of utilizing machine learning models to unravel information from multi-omics data. The integration of Ribo-seq with other omics data, such as RNA-seq, is essential to understand the gene expression in complex biological systems.
He, Xiaona (58653364300); Chen, Huiting (58753097200); Zhu, Xinyu (58753327700); Gao, Wei (37052008600)
Non-pharmaceutical interventions in containing COVID-19 pandemic after the roll-out of coronavirus vaccines: a systematic review
2024
10.1186/s12889-024-18980-2
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195438657&doi=10.1186%2fs12889-024-18980-2&partnerID=40&md5=ebc1c69bc6884a90e4758fc81966bfd7
Department of Epidemiology and Health Statistics, School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang, China; Jiangxi Provincial Key Laboratory of Preventive Medicine and Public Health, Nanchang University, No. 461, Bayi Ave,, Nanchang, 330006, China
All Open Access; Gold Open Access
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