Artículo

Biomarkers for neuromyelitis optica: a visual analysis of emerging research trends

Resumen

Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system that differs from multiple sclerosis. Over the past 20 years, the search for biomarkers for neuromyelitis optica has been ongoing. Here, we used a bibliometric approach to analyze the main research focus in the field of biomarkers for neuromyelitis optica. Research in this area is consistently increasing, with China and the United States leading the way on the number of studies conducted. The Mayo Clinic is a highly reputable institution in the United States, and was identified as the most authoritative institution in this field. Furthermore, Professor Wingerchuk from the Mayo Clinic was the most authoritative expert in this field. Keyword analysis revealed that the terms “neuromyelitis optica” (261 times), “multiple sclerosis” (220 times), “neuromyelitis optica spectrum disorder” (132 times), “aquaporin 4” (99 times), and “optical neuritis” (87 times) were the most frequently used keywords in literature related to this field. Comprehensive analysis of the classical literature showed that the majority of publications provide conclusive research evidence supporting the use of aquaporin-4-IgG and neuromyelitis optica-IgG to effectively diagnose and differentiate neuromyelitis optica from multiple sclerosis. Furthermore, aquaporin-4-IgG has emerged as a highly specific diagnostic biomarker for neuromyelitis optica spectrum disorder. Myelin oligodendrocyte glycoprotein-IgG is a diagnostic biomarker for myelin oligodendrocyte glycoprotein antibody-associated disease. Recent biomarkers for neuromyelitis optica include cerebrospinal fluid immunological biomarkers such as glial fibrillary acidic protein, serum astrocyte damage biomarkers like FAM19A5, serum albumin, and gamma-aminobutyric acid. The latest prospective clinical trials are exploring the potential of these biomarkers. Preliminary results indicate that glial fibrillary acidic protein is emerging as a promising candidate biomarker for neuromyelitis optica spectrum disorder. The ultimate goal of future research is to identify non-invasive biomarkers with high sensitivity, specificity, and safety for the accurate diagnosis of neuromyelitis optica.
Bulto, Tadesse Weyuma (57218921685); Chebo, Abdella Kosa (57211658384); Regassa, Hailu Fufa (59527811700); Werku, Birhanu Chalchisa (57793656500); Kloos, Helmut (26643043000)
Scientific mapping of the nexus between entrepreneurial orientation and environmental sustainability: bibliometric analysis
2024
10.3389/fsoc.2024.1461840
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85216004215&doi=10.3389%2ffsoc.2024.1461840&partnerID=40&md5=eb475c40557b00c5f84aa42ba2e3e68d
Department of Management, Kotebe University of Education, Addis Ababa, Ethiopia; Department of Business Management, University of Johannesburg, Johannesburg, South Africa; Department of Sociology, Ambo University, Oromia, Ethiopia; Faculty of Resource Management and Economics, Wollega University, Nekemte, Ethiopia; Department of Rural Development and Agricultural Extension, Jimma University, Jimma, Ethiopia; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, United States
All Open Access; Gold Open Access
Scopus
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