Artículo

The Xylitol Applicability and its Effects in Health Area Worldwide: A Bibliometric Analysis Based on Randomized Controlled Trials

Resumen

Objective: To describe and evaluate the xylitol products’ applicability and its effects in the health area worldwide utilizing a bibliometric analysis from randomized controlled trials (RCT) with humans. Material and Methods: Electronic searches were carried out in Medline/PubMed, Scopus, Cochrane Library, Web of Science, and VHL databases. The main data extracted were: year, area of applicability, type of treatment, country, journal, xylitol posology and concentration, presentation form, outcomes, and effects. Results: From 1476 studies, 257 were included. These studies were published between 1973-2021. The majority was carried out in dentistry (78.9%) and under preventive treatment (67.4%). These studies were developed in the USA (15.4%) and published in Caries Research (6.6%). The posology and concentration ranged between 0.004-67 g/day and 0.002-100%, respectively. The xylitol is usually used in the chewing gum form (44.0%), and for antimicrobial activity evaluation (38.5%). A positive effect was observed in 204 studies (79.3%) and was associated with xylitol concentration >= 15% (p=0.007). Side effects were reported in 8.2% and were associated with posology >= 5 g/day (p=0.05). Conclusion: Most studies with xylitol were conducted to prevent diseases in the dentistry field. The chewing gum form and antimicrobial activity evaluation were more frequent. Most xylitol products have a positive effect, and few studies report side effects.
Zeng, Lin (59304657200); Shi, Yihan (59304657100); Subatijang, Parhati (59350252900); Zhang, Lei (59350368800); Gao, Jian (59276502500); Sun, Rongxin (56574635100); Jiang, Kan (57370621600)
Global research trends and hotspots in rheumatoid arthritis joint replacement:Bibliometric analysis and visualization study
2025
10.1016/j.jor.2024.09.017
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85205361667&doi=10.1016%2fj.jor.2024.09.017&partnerID=40&md5=4229a5e01e71046df9b23673cd8f5a62
Affiliated to the Sixth Affiliated Hospital of Xinjiang Medical University, China
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Scopus
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