Artículo

Treatments for Onychomycosis: A Bibliometric Analysis

Resumen

Introduction: Oral antifungals were the earliest treatments to receive approval for the management of onychomycosis and have a long-standing record to support their efficacy. Topical antifungals and device-based treatments have been explored and some implemented in more recent years as alternatives to traditional oral antifungals. The present bibliometric analysis summarizes trends in publication frequency for onychomycosis treatment modalities over time and characterizes their body of literature in terms of types of studies available and relative level of evidence. Methods: A comprehensive literature search was performed using Web of Science and SCOPUS databases. Results: Covering all publications from 1970 to present day, our search identified oral therapeutics n = 295 articles (n = 63 randomized control trials [RCTs]), topical therapeutics n = 358 articles (n = 72 RCTs), and device-based treatments n = 158 articles (n = 37 RCTs). Spikes in research activity surround FDA approval of therapeutics for each treatment modality. Research activity within the last decade has focused on topical and device-based treatments. Evidence for efficacy of device-based treatments is lacking from relatively few high-quality RCTs. Conclusion: With growing concern for non-dermatophyte mold onychomycosis and terbinafine resistance, researchers should validate the efficacy and safety of device-based treatments with high-quality studies.
Gupta, Aditya K. (35476368700); Taylor, Daniel (59174326800); Polla Ravi, Shruthi (57231440800); Wang, Tong (57608893500); Talukder, Mesbah (57226303680)
Treatments for Onychomycosis: A Bibliometric Analysis
2024
10.1159/000539822
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85199984550&doi=10.1159%2f000539822&partnerID=40&md5=7b1870934fd66bfc92a4d5519c12f6b7
Mediprobe Research Inc., London, ON, Canada; Division of Dermatology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; School of Pharmacy, Brac University, Dhaka, Bangladesh
All Open Access; Hybrid Gold Open Access
Scopus
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