Evolutionary Trend Analysis of Research on Immunotherapy for Brain Metastasis Based on Machine-Learning Scientometrics 2024

Brain metastases challenge cancer treatments with poor prognoses, despite ongoing advancements. Immunotherapy effectively alleviates advanced cancer, exhibiting immense potential to revolutionize brain metastasis management. To identify research priorities that optimize immunotherapies for brain metastases, 2164 related publications were analyzed. Scientometric visualization via R software, VOSviewer, and CiteSpace showed the interrelationships among literature, institutions, authors, and topic areas of focus. The publication rate and citations have grown exponentially over the past decade, with the US, China, and Germany as the major contributors. The University of Texas MD Anderson Cancer Center ranked highest in publications, while Memorial Sloan Kettering Cancer Center was most cited. Clusters of keywords revealed six hotspots: ‘Immunology’, ‘Check Point Inhibitors’, ‘Lung Cancer’, ‘Immunotherapy’, ‘Melanoma’, ‘Breast Cancer’, and ‘Microenvironment’. Melanoma, the most studied primary tumor with brain metastases offers promising immunotherapy advancements with generalizability and adaptability to other cancers. Our results outline the holistic overview of immunotherapy research for brain metastases, which pinpoints the forefront in the field, and directs researchers toward critical inquiries for enhanced mechanistic insight and improved clinical outcomes. Moreover, governmental and funding agencies will benefit from assigning financial resources to entities and regions with the greatest potential for combating brain metastases through immunotherapy.

Autores	Saltos-Cruz, Gabriel (57467165400); Araque-Jaramillo, Wilson (57467021300); Saltos-Cruz, Carlos (57673075400)
Año	2022
DOI	10.52080/rvgluz.27.7.13
Fuente	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129748068&doi=10.52080%2frvgluz.27.7.13&partnerID=40&md5=7ab6e08bf9f88fe11a4cee81b5dc34fe
Afiliaciones	Universidad Andina Simón, Bolívar, Ecuador; Universidad Técnica de Ambato (UTA), Ecuador
Tipo de acceso abierto	All Open Access; Gold Open Access; Green Open Access
Referencia	Scopus
Artículo obtenido de:	Scopus

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Evolutionary Trend Analysis of Research on Immunotherapy for Brain Metastasis Based on Machine-Learning Scientometrics

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