Artículo

The impact of social isolation and loneliness on cardiovascular disease risk factors: a systematic review, meta-analysis, and bibliometric investigation

Resumen

Data on the association between social isolation, loneliness, and risk of incident coronary heart disease (CVD) are conflicting. The objective of this study is to determine the relationship between social isolation and loneliness, and the risk of developing cardiovascular disease (CVD) in middle age and elderly using meta-analysis. The purpose of the bibliometric analysis is to systematically evaluate the existing literature on the relationship between social isolation, loneliness, and the risk of developing cardiovascular disease (CVD) in middle-aged and elderly individuals. A comprehensive search through four electronic databases (MEDLINE, Google Scholar, Scopus, and Web of Science) was conducted for published articles that determined the association between social isolation and/or loneliness and the risk of developing coronary heart disease from June 2015 to May 2023. Two independent reviewers reviewed the titles and abstracts of the records. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline to conduct the systematic review and meta-analysis. Data for the bibliometric analysis was obtained from the Scopus database and analyzed using VOSviewer and Bibliometrix applications. Six studies involving 104,511 patients were included in the final qualitative review and meta-analysis after screening the records. The prevalence of loneliness ranged from 5 to 65.3%, and social isolation ranged from 2 to 56.5%. A total of 5073 cardiovascular events were recorded after follow-up, ranging between 4 and 13 years. Poor social relationships were associated with a 16% increase in the risk of incident CVD (Hazard Ratio of new CVD when comparing high versus low loneliness or social isolation was 1.16 (95% Confidence Interval (CI) 1.10–1.22). The bibliometric analysis shows a rapidly growing field (9.77% annual growth) with common collaboration (6.37 co-authors/document, 26.53% international). The US leads research output, followed by the UK and Australia. Top institutions include University College London, Inserm, and the University of Glasgow. Research focuses on “elderly,” “cardiovascular disease,” and “psychosocial stress,” with recent trends in “mental health,” “social determinants,” and “COVID-19”. Social isolation and loneliness increase the risk of and worsen outcomes in incident cardiovascular diseases. However, the observed effect estimate is small, and this may be attributable to residual confounding from incomplete measurement of potentially confounding or mediating factors. The results of the bibliometric analysis highlight the multidimensional nature of CVD research, covering factors such as social, psychological, and environmental determinants, as well as their interplay with various demographic and health-related variables.
albasheer, Osama (57191897334); Abdelwahab, Siddig Ibrahim (26029049500); Zaino, Mohammad R. (57463026700); Altraifi, Ahmed Abdallah Ahmed (58300517700); Hakami, Nasser (57215841558); El-Amin, Ehab I. (56533875000); Alshehri, Mohammed M. (57201588630); Alghamdi, Saeed M. (57205671323); Alqahtani, Abdulfattah S. (57060106700); Alenazi, Aqeel M. (56345932000); Alqahtani, Bader (57140604300); Alhowimel, Ahmed (57204074553); Uddin, Shadab (58075287900); Khalafalla, Husam Eldin Elsawi (55542538500); Medani, Isameldin E. (58615591900)
The impact of social isolation and loneliness on cardiovascular disease risk factors: a systematic review, meta-analysis, and bibliometric investigation
2024
10.1038/s41598-024-63528-4
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195252333&doi=10.1038%2fs41598-024-63528-4&partnerID=40&md5=7b77a1f99a51294c9810f2ccf6a2c00d
Family and Community Medicine Department, Faculty of Medicine, College of Medicine, Jazan University, Jazan, 45142, Saudi Arabia; Health Research Centre, Jazan University, Jazan, Saudi Arabia; Physical Therapy Department, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia; Obstetrics and Gynaecology Department, College of Medicine, Jazan University, Jazan, Saudi Arabia; Surgical Department, College of Medicine, Jazan University, Jazan, Saudi Arabia; Department of Epidemiology, College of Public Health and Tropical Medicine, Jazan University, Jazan, Saudi Arabia; Department of Physical Therapy, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia; Clinical Technology Department, Respiratory Care Program, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia; Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; Health and Rehabilitation Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia; Department of Health Education and Promotion, School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands
All Open Access; Gold Open Access
Scopus
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