Artículo

A bibliometric analysis of alternative drug therapy options in the treatment of androgenetic alopecia

Resumen

Background Oral finasteride and topical minoxidil formulations are the only FDA-approved drug therapies for androgenetic alopecia (AGA). Research into dutasteride, topical finasteride, and nontopical minoxidil (low-dose oral and sublingual) formulations in the treatment of AGA has spiked within recent years. Early findings show that these alternative drug therapies may have similar to improved efficacy and safety profiles relative to the conventional treatment options. Aims Conducting a bibliometric analysis, compare trends in publications on these alternative drug therapies, identify key contributors, evaluate major findings from top-cited articles, and elucidate gaps in evidence. Methods A search was conducted on the Web of Science database for publications on the use of alternative drug therapies in the treatment of AGA. A total of 95 publications, published between January 2003—March 2024, and their citation metadata were included in the analysis. Results Dutasteride showed the greatest (n = 37) and longest (20+ years) history of publications, as well as the highest cumulative citations (n = 914); however, nontopical minoxidil showed a burst in research activity within the last 5 years (n = 33 publications since 2019). A relatively low number of randomized control trials (n = 3) for nontopical minoxidil suggests a need for higher-quality evidence. Conclusions Our analysis reveals major trends, contributors, and gaps in evidence for alternative drug therapies for AGA, which can help inform researchers on their future projects in this growing field of study. There is enthusiasm for exploring off-label formulations: nontopical forms of minoxidil (oral and sublingual), topical finasteride, and mesotherapy.
Gupta, Aditya K. (35476368700); Taylor, Daniel (59174326800); Ravi, Shruthi Polla (57865615900); Wang, Tong (57608893500); Talukder, Mesbah (57226303680)
A bibliometric analysis of alternative drug therapy options in the treatment of androgenetic alopecia
2024
10.1111/jocd.16427
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196110765&doi=10.1111%2fjocd.16427&partnerID=40&md5=920bb0d7061b553eb22b690c5dbdfd25
Mediprobe Research Inc., London, ON, Canada; Division of Dermatology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; School of Pharmacy, BRAC University, Dhaka, Bangladesh
All Open Access; Hybrid Gold Open Access
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