Artículo

A review of Ribosome profiling and tools used in Ribo-seq data analysis

Resumen

Translational regulation plays the most critical role in gene expression. Ribosome profiling sequencing (Ribo-Seq) is one of the methods to study translation and its regulation. It is a high throughput technology based on deep sequencing, which targets ribosome protected mRNA fragments to produce a ‘global snapshot’ of translatome. There has been an annual increase in the number of publications incorporating Ribo-seq technology. Because of its importance, we used PubMed database to conduct a comprehensive bibliometric analysis on Ribo-seq. We identified 2744 published articles that utilized the term ‘Ribo-seq’ between 2009 and Jan 2024, and 684 articles that contained both Ribo-seq and RNA-seq terms. Based on keywords correlation analysis, we discovered that the primary focus of Ribo-seq articles lies in the areas of translation, transcriptome, and ribosome in the past few years and other topics such as single-cell ribo-seq and crispr within two years, reflecting current areas of interests in Ribo-seq research. The Ribo-seq data analysis applications were also explored and summarized, providing a guide for researchers to choose corresponding tools for different types of analysis. Overall, we highlighted the advances made by Ribo-seq technologies, and the possibilities of utilizing machine learning models to unravel information from multi-omics data. The integration of Ribo-seq with other omics data, such as RNA-seq, is essential to understand the gene expression in complex biological systems.
De Iuliis, Melissa (57204807865); Cardoni, Alessandro (57200816744); Paolo Cimellaro, Gian (58916210700)
Resilience and safety of civil engineering systems and communities: A bibliometric analysis for mapping the state-of-the-art
2024
10.1016/j.ssci.2024.106470
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85186519876&doi=10.1016%2fj.ssci.2024.106470&partnerID=40&md5=9bd8cb41d13f5a4026706ab508301d02
Dept. of Structural and Geotechnical Engineering, Sapienza University of Rome, Via Eudossiana, 18, Rome, Italy; Dept. of Structural, Geotechnical and Building Engineering, Politecnico di Torino, Corso Duca degli Abruzzi, 24, Torino, Italy
All Open Access; Hybrid Gold Open Access
Scopus
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